Regenerative medicine represents a transformative approach to healthcare, focused on repairing or replacing damaged tissues and organs to restore normal function. Synthetic biology is revolutionizing the field of regenerative medicine by enabling the creation of intelligent biomaterials that not only support tissue regeneration, but also actively participate in tissue repair and regeneration. These materials are characterized by their ease of engineering, excellent biosafety, and responsiveness to stimuli at target sites, which hold immense potential in applications such as connective tissue repair, bone regeneration, and disease treatment. complex such as diabetic foot ulcers. Additionally, integrating advanced manufacturing techniques, such as 3D and 4D printing, with these smart materials further improves their efficiency, enabling the creation of anatomically precise and functionally dynamic constructs.

Despite significant progress in the field of smart biomaterials, the ultimate goal of precise, on-demand tissue regeneration remains a significant challenge in this field. One of the key challenges is the development of materials capable of faithfully mimicking the complex biological environments of different tissues while adapting to the dynamic conditions of the human body. The objective of this research topic is to explore innovative approaches for the design, manufacturing and application of smart biomaterials in regenerative medicine. Recent advances in synthetic biology have spurred the development of a variety of bioinspired polymer-based materials, such as protein coatings and ECM-like hydrogels. Synthetic biology notably allows the programming of biological systems at the genetic level, offering promising avenues for creating hybrid living materials capable of responding to environmental stimuli. Additionally, the development of stimuli-responsive materials that change their properties in response to specific triggers may lead to more effective and personalized treatments. By addressing these challenges, this research topic aims to advance the field toward the creation of next-generation biomaterials that could revolutionize tissue and organ regeneration.

This research topic invites contributions that explore the design, development and application of smart biomaterials in regenerative medicine. We are accepting submissions on the following topics: the use of synthetic biology in materials design, the development of hybrid living materials, the creation of stimuli-responsive materials and the application of these materials in connective tissue repair, organ regeneration, bone regeneration and treatments for other complex clinical conditions such as diabetic foot ulcers and inflammatory bowel disease (IBD). We encourage a variety of manuscript types, including original research articles, reviews, case studies, and perspectives that provide new insights or challenge existing paradigms. Submissions should focus on innovative strategies that address current limitations and propose new directions for the use of smart biomaterials in preclinical settings.

Keywords: Smart biomaterials, Synthetic biology, Regenerative medicine, Living therapy, Tissue regeneration

Important note: All contributions to this research topic must fall within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more appropriate section or journal at any stage of peer review.

Regenerative medicine represents a transformative approach to healthcare, focused on repairing or replacing damaged tissues and organs to restore normal function. Synthetic biology is revolutionizing the field of regenerative medicine by enabling the creation of intelligent biomaterials that not only support tissue regeneration, but also actively participate in tissue repair and regeneration. These materials are characterized by their ease of engineering, excellent biosafety, and responsiveness to stimuli at target sites, which hold immense potential in applications such as connective tissue repair, bone regeneration, and disease treatment. complex such as diabetic foot ulcers. Additionally, integrating advanced manufacturing techniques, such as 3D and 4D printing, with these smart materials further improves their efficiency, enabling the creation of anatomically precise and functionally dynamic constructs.

Despite significant progress in the field of smart biomaterials, the ultimate goal of precise, on-demand tissue regeneration remains a significant challenge in this field. One of the key challenges is the development of materials capable of faithfully mimicking the complex biological environments of different tissues while adapting to the dynamic conditions of the human body. The objective of this research topic is to explore innovative approaches for the design, manufacturing and application of smart biomaterials in regenerative medicine. Recent advances in synthetic biology have spurred the development of a variety of bioinspired polymer-based materials, such as protein coatings and ECM-like hydrogels. Synthetic biology notably allows the programming of biological systems at the genetic level, offering promising avenues for creating hybrid living materials capable of responding to environmental stimuli. Additionally, the development of stimuli-responsive materials that change their properties in response to specific triggers may lead to more effective and personalized treatments. By addressing these challenges, this research topic aims to advance the field toward the creation of next-generation biomaterials that could revolutionize tissue and organ regeneration.

This research topic invites contributions that explore the design, development and application of smart biomaterials in regenerative medicine. We are accepting submissions on the following topics: the use of synthetic biology in materials design, the development of hybrid living materials, the creation of stimuli-responsive materials and the application of these materials in connective tissue repair, organ regeneration, bone regeneration and treatments for other complex clinical conditions such as diabetic foot ulcers and inflammatory bowel disease (IBD). We encourage a variety of manuscript types, including original research articles, reviews, case studies, and insights that provide new insights or challenge existing paradigms. Submissions should focus on innovative strategies that address current limitations and propose new directions for the use of smart biomaterials in preclinical settings.

Keywords: Smart biomaterials, Synthetic biology, Regenerative medicine, Living therapy, Tissue regeneration

Important note: All contributions to this research topic must fall within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more appropriate section or journal at any stage of peer review.